Grapeseed oil, a byproduct of winemaking, has garnered interest as a potential topical treatment for various skin conditions. Several randomized controlled trials (RCTs) have investigated its efficacy in improving skin health, focusing on its purported antioxidant and anti-inflammatory properties. These studies explore whether grapeseed oil can offer a beneficial therapeutic approach for skin concerns.
Protocols Studied in Research
[1] Grapeseed oil-loaded nanoemulgel for improving facial skin biophysical parameters. (Cited by: 0) (pmid: 35713012)
- Protocol: A 12-week, split-face, blinded, placebo-controlled study with 15 healthy volunteers comparing a grapeseed oil nanoemulgel to a placebo, assessing weekly changes in melanin, erythema, sebum, pores, moisture, and elasticity.
- Outcome: The grapeseed oil nanoemulgel significantly improved sensory attributes and reduced melanin, erythema, sebum, and pore size while increasing skin moisture and elasticity compared to placebo.
Research Interpretation: Summary and Conclusion
A single clinical trial (PMID 35713012) investigated the effects of grapeseed oil nanoemulgel on skin health in a 12-week, split-face, blinded, placebo-controlled study involving 15 healthy volunteers. The study employed rigorous methodology, assessing multiple skin parameters including melanin, erythema, sebum production, pore size, moisture, and elasticity. Consistent findings across this single study demonstrated that the grapeseed oil nanoemulgel significantly improved several key skin attributes. Specifically, the treatment led to a reduction in melanin, erythema, sebum, and pore size, alongside increases in skin moisture and elasticity compared to the placebo. Further research with larger sample sizes and diverse populations is needed to confirm these promising results and to explore the potential long-term effects of grapeseed oil on skin. The absence of additional studies limits the generalizability of these findings. The current evidence suggests a potential benefit of topical grapeseed oil nanoemulgel for improving various aspects of skin health.
Publications
[1] Shawahna R (2022). Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split-face, blinded, placebo-controlled study Journal of cosmetic dermatology 21 (11) :5730-5738.
