Research Publications on Magnesium for Mood

Magnesium: Nature’s physiological mood stabilizer; Trace Elements and Electrolytes, 2020; Link

Magnesium (Mg) is recognized as a potent "physiologic mood stabilizer" due to extensive data from various studies including in-vivo and in-vitro experiments, epidemiological research, and clinical trials. This role is especially significant given the high incidence of latent magnesium deficiency in Western populations and the rising prevalence of mood disorders. Magnesium therapy, which is safe and generally well-accepted, helps stabilize mood. Experimental evidence links magnesium with effects on the central nervous system, influencing conditions like tetanus and producing sedative effects, thereby supporting its clinical use in mood regulation.

Magnesium for treatment-resistant depression: A review and hypothesis; Medical Hypotheses, 2010; Link

Magnesium deficiency is significantly implicated in treatment-resistant depression (TRD), affecting 60% of clinical depression cases. Magnesium's role in modulating N-methyl-d-aspartate (NMDA) receptors linked to neuronal injury and depression is highlighted by its antidepressant-like effects in animals and low levels found in TRD patients. Despite historical success in treating agitated depression since 1921 and modern case reports confirming rapid TRD alleviation with magnesium, few clinical trials exist. A 2008 study showed magnesium's efficacy equal to the antidepressant imipramine without side effects. Given its role in serotonin regulation and antidepressant effects, magnesium supplementation is proposed as a critical, broadly effective treatment for TRD, necessitating more comprehensive research and clinical use.

Magnesium and depression; Magnesium Research, 2016; Link

Magnesium is essential for numerous bodily functions, including cardiovascular, digestive, endocrine, and skeletal systems, and plays a crucial role in brain biochemistry related to neurotransmission and depression. Deficiency can cause personality changes such as apathy, confusion, and anxiety, and has been linked to conditions like poor nutrition, diabetes, and stress. Studies confirm magnesium's mood-enhancing effects, suggesting that supplementation can boost conventional antidepressant treatments, making it a promising adjunct in managing depression. However, the effectiveness may vary between inorganic and organic forms of magnesium supplements.