Tranexamic Acid for Skin

Tranexamic acid reduces psoriasis-like inflammation, keratinocyte hyperproliferation, and inflammatory signaling, while treating various skin disorders.

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Research Interpretation

Tranexamic acid (TXA), a lysine derivative and antifibrinolytic, demonstrates significant dermatological benefits. In psoriasis models, TXA reduces erythema, thickness, scaling, hyperkeratosis, and inflammation, suppressing NFκB and NLRP3 inflammasome pathways, while enhancing autophagy and downregulating keratin 17. Clinically, TXA is effective for melasma, acne, rosacea, post-inflammatory hyperpigmentation, and angioedema due to its anti-inflammatory, anti-angiogenic, and melanogenesis-inhibiting properties. It can be administered orally, topically, or via intradermal injection, alone or with other therapies, highlighting its versatile and promising role in dermatological treatments.

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