Argireline, a synthetic hexapeptide derived from SNAP-25, shows significant anti-wrinkle effects in both humans and animal models. Clinical studies in Chinese subjects demonstrated notable reductions in periorbital wrinkle depth, with an overall anti-wrinkle efficiency of 48.9%. In aged mice, Argireline improved skin histology by increasing type I collagen and decreasing type III collagen, indicating tissue rejuvenation. The peptide is well tolerated and safe, supporting its potential as a cosmetic ingredient for reducing facial wrinkles and improving skin structural integrity.
Publication
- The Anti-Wrinkle Efficacy of Argireline; Yuan Wang, Mei Wang, Xiang Sheng Xiao, Jia Huo, Wei Ding Zhang; Journal of Cosmetic and Laser Therapy, Vol. 15(4), 237–241, 2013
- The Anti-Wrinkle Efficacy of Synthetic Hexapeptide (Argireline) in Chinese Subjects; Yuan Wang, Mei Wang, Xiang Sheng Xiao, Ping Pan, Ping Li, Jia Huo; Journal of Cosmetic and Laser Therapy, Vol. 15(4), 237–241, 2012
